The secure polypill trial

Author: iida

August undefined, 2024

WebA polypill is a type of drug combination consisting of a single drug product in pill form (i.e., tablet or capsule) and thus combines multiple medications (that is, more than one active … WebAug 15, 2024 · Although a long-term prospective randomized clinical trial, the SECURE study (Secondary prevention of cardiovascular disease in the elderly) it is currently ongoing, for the time being, data about the efficacy of the CNIC-Polypill on MACE in secondary prevention patients are lacking.

SECURE Trial Summary: Polypill Strategy in Secondary …

http://www.secure-h2024.eu/ WebSep 20, 2024 · In the SECURE trial, a polypill containing aspirin, ramipril and atorvastatin taken within 6 months after myocardial infarction reduces the risk of major adverse … rachael holley

Polypill Therapy in Cardiovascular Disease: A Meta-analysis of

WebOct 30, 2014 · The study will assess whether a polypill approach is associated with better cardiovascular risk factor control compared with usual care. The polypill will be supplied … WebAug 24, 2024 · The PolyIran study was a two-group, pragmatic, cluster-randomised trial nested within the GCS, a cohort study with 50 045 participants aged 40–75 years from the Golestan province in Iran. 20% of GCS participants were enrolled from Gonbad city and 80% from rural areas covering the villages in Gonbad, Aq-Qala, and Kalaleh districts. WebDec 8, 2024 · To the Editor: In their article on the Secondary Prevention of Cardiovascular Disease in the Elderly (SECURE) trial, Castellano et al. (Sept. 15 issue) 1 report that … rachael hocking bio

Polypill SECUREs win in secondary prevention in elderly

Polypill for Cardiovascular Disease Prevention in an Underserved ...

WebAug 26, 2024 · It has been proposed that a polypill containing all three treatments would make it easier for patients to adhere to their medication. SECURE was the first … WebNov 13, 2024 · For the comparison of the polypill with placebo, 81.1% of the participants in the polypill group and 81.3% of those in the placebo group were adhering to the trial regimen at 24 months; at 48 ... rachael hodgesWebDec 2, 2024 · SECURE will be the first trial testing the efficacy of a fixed dose combination (FDC) polypill for secondary cardiovascular prevention in the elderly population (≥ 65 years old). The main objective is to evaluate the potential benefit of the FDC as a component of a cost-effective, globally available and comprehensive treatment strategy for ... rachael holliday

"WebAug 26, 2024 · MADRID-- ( BUSINESS WIRE )--The polypill developed by the CNIC and Ferrer, which includes three drugs (aspirin, an angiotensin-converting enzyme (ACE) inhibitor, and a statin), is effective at... " - The secure polypill trial

The secure polypill trial

Polypill Bests Usual Care in Patients With Recent MI: SECURE

WebThe polypill reduces mortality from cardiovascular causes in this population by 33%. ... The SECURE trial analyzed the incidence of four major cardiovascular events: death from cardiovascular causes, non-fatal myocardial infarction, non-fatal stroke, and emergency coronary revascularization (the restoration of blood flow through a blocked ... WebAug 25, 2024 · Treatment with a polypill containing aspirin, ramipril, and atorvastatin within six months after myocardial infarction resulted in a significantly lower risk of major …

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WebAug 26, 2024 · A three-drug medication known as a "polypill," developed by the Spanish National Center for Cardiovascular Research (CNIC) and Ferrer, is effective in preventing … WebAug 26, 2024 · A three-drug medication known as a “polypill,” developed by the Spanish National Center for Cardiovascular Research (CNIC) and Ferrer, is effective in preventing …

WebAug 26, 2024 · The polypill analyzed in the study, commercialized under the name Trinomia, contains aspirin (100 mg), the angiotensin-converting enzyme inhibitor ramipril (2.5, 5, or 10 mg), and atorvastatin... WebAug 26, 2024 · A polypill strategy has been pursued for more than 15 years, according to Dr. Fuster. Other polypill studies have also generated positive results, but the latest trial, called SECURE, is the largest prospective randomized trial to evaluate a single pill combining multiple therapies for secondary prevention.

WebDec 9, 2024 · The manufacturer-supplied polypill contained simvastatin 40 mg plus three antihypertensive medications (100-mg atenolol, 25-mg hydrochlorothiazide, and 10-mg … WebAug 26, 2024 · Importantly, the study found that patients in the polypill group had a higher level of treatment adherence than those in the control group, thus confirming the findings of the earlier FOCUS study, and in part such good adherence appears to explain the benefits of the simple polypill. “The SECURE study findings suggest that the polypill could ...

WebAug 26, 2024 · August 29, 2024. 2024 SECURE TRIAL Polypill Strategy in Secondary Cardiovascular Prevention Phase 3, randomized, controlled clinical trial Objective: To evaluate the effect of polypill that includes key medications (aspirin, ramipril, and atorvastatin) on cardiovascular events in post-Ml patients. 2499 Inclusion criteria: …

WebThe polypill consisted of four low-dose medications: atorvastatin (10 mg), amlodipine (2.5 mg), losartan (25 mg), and hydrochlorothiazide (12.5 mg). Generic versions were placed securely in... shoe meansWebAug 26, 2024 · In the SECURE trial, a treatment strategy for secondary prevention with a polypill containing aspirin, ramipril, and atorvastatin in older patients with recent … rachael horsmanWebThe article presents a clinical case of application of a new drug form, i.e. polypill of amlodipine, atorvastatin, and perindopril, in a patient with type 2 diabetes mellitus. The problems of complication risk assessment and treatment strategy are reviewed. shoe measure guideWebSep 2, 2024 · “The results of the SECURE study show that for the first time that the polypill, which contains aspirin, ramipril, and atorvastatin, achieves clinically relevant reductions in … shoe measurements in cmWebAug 26, 2024 · The SECURE trial showed that a polypill strategy (aspirin, statin, ACE inhibitor) can prevent adverse cardiovascular events. Description: The goal of the trial … shoe measurements for kidsWebSep 20, 2024 · In the SECURE trial, a polypill containing aspirin, ramipril and atorvastatin taken within 6 months after myocardial infarction reduces the risk of major adverse cardiovascular events compared ... shoe measurementWebAug 26, 2024 · In SECURE, the polypill strategy reduced the risk of cardiovascular death, nonfatal MI, nonfatal ischemic stroke, or urgent revascularization, the study’s primary … shoe measurements in inches