Webb5 aug. 2014 · A more detailed analysis of the interaction between transcription factors and SPTBN1 and/or SMAD3 in the regulation of STAT3 transcription, and of the connection between this interaction and TGF-β signaling should elucidate mechanisms underlying the pathogenesis of liver cancer and inform a combination treatment strategy for this … WebbZawel L, Dai JL, Buckhaults P, et al. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1998;1:611–617. CrossRef CAS PubMed Google Scholar Zhang Y, Feng XH, Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature 1998;394:909–913.
Gene Set - SMAD3
WebbInterestingly, mutations which eliminate the Smad DNA binding site do not interfere with either TGF-β-dependent transcriptional activation or activation by Smad3/Smad4 cooverexpression. In contrast, mutation of adjacent AP1 sites within this context eliminates both TGF-β-dependent transcriptional activation and activation in response to … Webb25 jan. 2024 · Unintended cardiac fibroblast proliferation in many pathophysiological heart conditions, known as cardiac fibrosis, results in pooling of extracellular matrix (ECM) proteins in the heart muscle. Transforming growth factor β (TGF-β) as a pivotal cytokine/growth factor stimulates fibroblasts and hastens ECM production in injured … react tailwind modal component
Regulators of Smad2/3 Transcription and Phosphorylation
WebbIn addition to the TGF-β/Smad pathway, NF-κB/p38/JNK also involved in inflammatory responses. 11, 12 NF-κB is an important nuclear transcription factor that regulates the transcription of genes such as inflammatory immune response and cell survival. 13 It has been confirmed that the increase in activated NF-κB is an important mechanism of … Webb25 sep. 2024 · In depth studies of the RNA-binding activities of several transcription factors, including SMAD3 and NF-B, show that RNA preference does not correlate to DNA sequence recognition although binding ... WebbThe SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, … how to stitch 2 photos together in photoshop